Donor Blood Cell-based Platform

− Electroporation of NKG2D RNA CAR Improves Vγ9Vδ2 T Cell Responses against Human Solid Tumor Xenografts

Ang WX, Ng YY, Xiao L, Chen C, Li Z, Chi Z, Tay JC, Tan WK, Zeng J, Toh HC, Wang S
Molecular Therapy: Oncolytics 2020, 17: 421

− Beta-2 microglobulin knockout K562 cell-based artificial antigen presenting cells for ex vivo expansion of T lymphocytes

Zha S, Li Z, Chen C, Du Z, Tay JC, Wang S
Immunotherapy 2019, 11: 967

– Large-scale expansion of Vgamma9Vdelta2 T cells with engineered K562 feeder cells in G-Rex vessels and their use as chimeric antigen receptor-modified effector cells

Xiao L, Chen C, Li Z, Zhu S, Tay JC, Zhang X, Zha S, Zeng J, Tan WK, Liu X, Chng WJ, Wang S
Cytotherapy 2018, 20:420-35

– Expansion of Gamma Delta T Cells – A Short Review on Bisphosphonate and K562-Based Methods

Tan WK, Tay JC, Zeng J, Zheng M, Wang S
Journal of Immunol Sciences 2018, 2(3): 6-12

– Chimeric switch receptor: switching for improved adoptive T-cell therapy against cancers

Tay JC, Zha S, Wang S
Immunotherapy 2017, 9:1339-49

– Intraperitoneal immunotherapy with T cells stably and transiently expressing anti-EpCAM CAR in xenograft models of peritoneal carcinomatosiss

Ang WX, Li Z, Chi Z, Du SH, Chen C, Tay JC, Toh HC, Connolly JE, Xu XH, Wang S:
Oncotarget 2017, 8:13545-59

– Co-Expansion of Cytokine-Induced Killer Cells and Vgamma9Vdelta2 T Cells for CAR T-Cell Therapy

Du SH, Li Z, Chen C, Tan WK, Chi Z, Kwang TW, Xu XH, Wang S
PloS one 2016, 11:e0161820

MSC-based platform

 Human iPS cell-derived fibroblast-like cells as feeder layers for iPS cell derivation and expansion

Du SH, Tay JC, Chen C, Tay FC, Tan WK, Li ZD, Wang S
Journal of bioscience and bioengineering 2015, 120:210-7

iPSC-based platform

− Derivation of mimetic gammadelta T cells endowed with cancer recognition receptors from reprogrammed gammadelta T cell

Zeng J, Tang SY, Wang S
PLoS One 2019, 14: e0216815

– Generation of “Off-the-Shelf” Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells

Zeng J, Tang SY, Toh LL, Wang S
Stem cell reports 2017, 9:1796-812.

– Antigenically Modified Human Pluripotent Stem Cells Generate Antigen-Presenting Dendritic Cells

Zeng J, Wu C, Wang S
Scientific reports 2015, 5:15262

– Human dendritic cells derived from embryonic stem cells stably modified with CD1d efficiently stimulate antitumor invariant natural killer T cell response

Zeng J, Wang S
Stem cells translational medicine 2014, 3:69-80

– Enhancing immunostimulatory function of human embryonic stem cell-derived dendritic cells by CD1d overexpression

Zeng J, Shahbazi M, Wu C, Toh HC, Wang S
Journal of immunology 2012, 188:4297-304

– The combined use of viral transcriptional and post-transcriptional regulatory elements to improve baculovirus-mediated transient gene expression in human embryonic stem cells

Zeng J, Shahbazi M, Wu C, Toh HC, Wang S
Journal of bioscience and bioengineering 2010, 109:1-8

– High-efficiency transient transduction of human embryonic stem cell-derived neurons with baculoviral vectors

Zeng J, Du J, Lin J, Bak XY, Wu C, Wang S
Molecular therapy 2009, 17:1585-93

–  Baculoviral vector-mediated transient and stable transgene expression in human embryonic stem cells

Zeng J, Du J, Zhao Y, Palanisamy N, Wang S
Stem cells 2007, 25:1055-61

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